Of course there are times when one should know when to give up or at least consider the advice that "if you keep doing what you've always done then you will always get what you always got" (reputedly said by Einstein).
A dogged determination does come in useful but can come at a cost in time, effort and often financially. Discrimination is needed when choosing how to act and when.
The astrological signs are that there are big shifts occuring yet again which are prompting each and every one of us to sit up and respond to an inner calling to be more authentic. This generally means going against the norm or the trend and can make us feel like outsiders. This too comes at a cost but being true to oneself always outways the potential losses in the long run.
So, get to know Percy Vere. He is a useful ally in these times!